|
Common name |
B-hFAP MC38 | Catalog number | 310825 |
| Aliases | DPPIVA, FAPalpha, SIMP | Disease | Colon carcinoma |
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Organism |
Mouse |
Strain | C57BL/6 |
| Tissue types | Colon | Tissue | Colon |
Description
Subcutaneous homograft tumor growth of B-hFAP MC38 cells. B-hFAP MC38 cells (1x106) and wild-type MC38 cells (1x106) were subcutaneously implanted into C57BL/6 mice (female, 7-week-old, n=5). Tumor volume and body weight were measured twice a week. (A) Average tumor volume. (B) Body weight. Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hFAP MC38 cells were able to establish tumors in vivo and can be used for efficacy studies. Values are expressed as mean ± SEM.
Tumor growth curve of individual mice
Tumor growth curve & Body weight changes
Subcutaneous homograft tumor growth of B-hFAP MC38 cells. B-hFAP MC38 cells and wild-type MC38 cells were subcutaneously implanted into B-hCD3E mice (female, 9-week-old, n=6). Tumor volume and body weight were measured twice a week. (A) Average tumor volume. (B) Body weight. Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hFAP MC38 cells were able to establish tumors in vivo and can be used for efficacy studies. Values are expressed as mean ± SEM.
B-hFAP MC38 cells were subcutaneously transplanted into C57BL/6 mice (n=5). At the end of the experiment, tumor cells were harvested and assessed for human FAP expression by flow cytometry. As shown, human FAP was highly expressed on the surface of tumor cells. Therefore, B-hFAP MC38 cells can be used for in vivo efficacy studies of novel FAP therapeutics.
Subcutaneous homograft tumor growth of B-hFAP MC38 cells. B-hFAP MC38 cells and wild-type MC38 cells were subcutaneously implanted into B-h4-1BB mice (female, 6-week-old, n=6). Tumor volume and body weight were measured twice a week. (A) Average tumor volume. (B) Body weight. Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hFAP MC38 cells were able to establish tumors in vivo and can be used for efficacy studies. Values are expressed as mean ± SEM.
